Coenzyme Q10 and the exclusive club of diseases that show a limited response to treatment

Introduction: Coenzyme Q10 (CoQ10) is a ubiquitous organic molecule with significant role in the mitochondrial electron transport chain (ETC). As result of its such an important biological process, CoQ10 deficiency has been implicated pathogenesis numerous diseases as Parkinson’s disease (PD) and multiple sclerosis (MS). This led to attempts use supplementation treatment or pre-treatment varying degrees success. Areas covered: The present review will identify evidence dysfunction MS, PD ETC disorders. In addition, inability Co10 elicit clinical outcome these disorders possible flaws studies be discussed. databases utilized for this were Web science PubMed, inclusive dates (1957–2021). Expert opinion: A lack improved neurological post may attributable limited ability cross blood–brain barrier. Thus, alternatives should also considered. Other factors including time diagnosis, dosage, administration, duration therapy have influence on efficacy treatment.